Individualized medical nutritional therapy (MNT)
for T1D or T2D, prediabetes and gestational diabetes
Reducing overall carbohydrate intake
MNT is the mainstay of prevention
and treatment of T2DM
A healthful eating pattern (low in saturated fat and sodium, and high in fruits, vegetables, wholegrain cereals and legumes) is recommended
for prediabetes and T2DM patients
Structured lifestyle intervention incorporating partial diet replacement can improve HbA1c, lipid profile and blood pressure
Adapted from Mortensen et al. 200919
Whey protein outperforms casein protein in lowering post-prandial blood glucose levels.
Adapted from Barakatun-Nisak, MY et al. 202018
HbA1c levels decreased significantly in the structured Ramadan Nutrition Plan Group (RNP) (-0.72 ± 0.16%, p<0.001).
Adapted from Phanachet P, et al. 202117
The PPG levels for the DSF group were significantly lower at 120 min (161.4 ±
37.9 mg/dL vs. 197.7 ± 56.8 mg/dL, p=0.005).
Adapted from Barakatun-Nisak, MY et al. 202018
The scores for satisfaction (−4.27 ± 0.96 vs. −2.13 ± 1.45) and QoL (−4.81 ± 1.55
vs. −0.74 ± 1.31) improved significantly in sRNT (p < 0.001) group as compared to the SC group.
About NUTREN® GlucoSmartT™
Adapted from Kim JY, et al. 201524
At week 4, the postprandial glycaemic response was significantly reduced in the mulberry leaf aqueous extract group, particularly at 30 and 60 minutes (p=0.003 and p=0.0325; respectively) vs. placebo.
Adapted from Riche DM, et al. 201725
Postprandial SMBG was significantly decreased at 3 months in the mulberry leaf extract group vs. baseline (16.1%; p<0.05). Improvement in postprandial SMBG persisted when compared to placebo (18.2%; p<0.05).
Adapted from Thaipitakwong T, et al. 202026
In obese persons who have borderline diabetes, mulberry leaf (12 mg DNJ) is markedly effective in lowering blood glucose concentration and HbA1c values.
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ADA: American Diabetes Association; DNJ: 1-deoxynojirimycin; DSF: diabetes-specific formula; GI: glycaemic index; HbA1c: haemoglobin A1c; MLE: Mulberry leaf extract; MNT: medical nutrition therapy; MUFA: monounsaturated fatty acids; PPG: postprandial glucose; SMBG: self-monitoring blood glucose; sRNT: structured Ramadan Nutrition Therapy; T1DM: type 1 diabetes mellitus; T2DM: type 2 diabetes mellitus
References: 1. Tan SL, Juliana S, Sakinah H. et al. Malays J Nutr. 2011 Dec;17(3):287-99; 2. Yu MH, et al. International Journal Academic Research in Business and Social Sciences. 2020 Nov; 10(16):96-108; 3. Forouhi NG. Diabetologia. 2023 May;66(5):786-799; 4. Md Isa Z, et al. BMC Nutr. 2023 Feb 7;9(1):27; 5. Ramadas A, et al. Nutrients. 2021 Apr 20;13(4):1380; 6. Shu PS, et al. PLoS One. 2017 Feb 24;12(2):e0172231; 7. Neblett RS, et al. Med J Malaysia. 2019 Dec;74(6):483-491; 8. Ajala O, et al. Am J Clin Nutr. 2013 Mar;97(3):505-516; 9. ADA Diabetes Care 2020; 10. Clinical Practice Guidelines Management of Type 2 Diabetes Mellitus (6th Edition) 2020; 11. Hussein Z, et al. Ann Glob Health. 2015 Nov-Dec;81(6):851-862 12. Mignone LE, et al. World J Diabetes 2015 October 25; 6(14): 1274-1284; 13. Park Y, et al. J Exerc Nutrition Biochem. 2019;23(2):34-44; 14. Xie J,et al. Adv Nutr. 2022 Oct 2;13(5):1901-1913; 15. Chen C, et al. Exp Ther Med. 2016 Aug;12(2):1232-1242; 16. Jenkins DJ, et al. CMAJ. 2010 Dec 14;182(18):1961-7; 17. Phanachet, P, et al. Journal of Nutrition Association of Thailand. 2021 Apr; 56(1), 1–12; 18. Mohd Yusof BN, et al. Nutrients. 2020 Mar 19;12(3):813; 19. Mortensen LS, et al. Am J Clin Nutr. 2009 Jul;90(1):41-8. 20. Jakubowicz D, et al. Diabetes Care 2015;38:1820-1826; 21. Park YM, et al. J Nutr 2015;145:452-458; 22. Gao K, et al. Molecules. 2016 Nov 23;21(11):1600; 23. Jakubowicz D, et al. J Nutr Biochem. 2017 Nov;49:1-7; 24. Kim JY, et al. J Med Food. 2015 Mar;18(3):306-13; 25. Riche DM, et al. Complement Ther Med. 2017 Jun;32:105-108. 26. Thaipitakwong T, et al. Complement Ther Med. 2020 Mar;49:102292.
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